On Wed, May 02, 2007 at 10:25:45AM +0300, Robert Iakobashvili wrote:
> The issue, that we have now is a certain performance degradation
> within tens of minutes upon a high CPU and low memory conditions .
> Shotting oprofile at such conditions is tricky, but we will try some tricks.
> We are suspecting intensive memory defragmentation efforts by glibc,
> which impacts the performance.

Have you tried tuning glibc's malloc?
http://www.gnu.org/software/libc/manual/html_node/Malloc-Tunable-Parameters.html
Or linking in an alternative allocator for comparison?

>>> Dan

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